Best Betaine Supplements Ranked for 2018 (Top 10 Brands)

Your body works very hard to keep you healthy.

You may not ever think about it, but it is working hard every second of the day to maintain your cells, tissues, and organs.

This requires energy, nutrients, and lots of biochemical reactions. Your body produces so many reactions that within 30 minutes, you will have released enough heat to boil a gallon of water.

Doesn’t that sound tiring?

It turns out that it is. Aging proves that. As you get older and continue to wear down your cells through energy production, consumption, and biochemical reactions that keep the process going.

This results in reduced levels of certain compounds that facilitate these reactions, because they are constantly being used.

One of these compounds is an amino acid called betaine, which supports the health of your body throughout your life.

As you age, the levels of betaine in your body decrease, which leaves you more vulnerable to cellular damage, toxification, and certain health conditions.

This is our official list of the best selling betaine supplements on the market.

These 10 betaine brands have been ranked because they dominate the e-commerce sales charts, fitness bloggers love them and they have the highest user reviews online.

Top 10 Betaine Products Compared

Heads up, there are affiliate links in this article, so if you buy something, we get a cut of the sale.


1. Transparent Labs RawSeries Betaine

Transparent-Labs-RawSeries-Betaine

Transparent Labs RawSeries Betaine is a raw betaine anhydrous supplement that comes in a powdered form. It is a great pre workout supplement that is easily stacked or taken alone. It can be taken with or without a meal, and it provides all of the best betaine benefits without any fillers. There are absolutely no extra ingredients.

Highlights:

  • Betaine anhydrous powder
  • No fillers are added ingredients
  • Affordable

What’s in it:

  • 5 g betaine anhydrous

Who makes it: Transparent Labs is a well known dietary supplement producer that strives for quality and integrity with every product. They are 100% transparent when it comes to their products, and you can trust that they are telling you everything that is in their supplements. They absolutely never use artificial sweeteners, food dyes, or harmful additives, and their RawSeries products are some of the most pure products on the market.

Bottom line: This is one of the top betaine supplements on the market right now. It offers pure betaine anhydrous in a powdered form that is easily stacked and allows for a customizable betaine dosage. This high quality supplement provides a large quantity of high quality betaine for an affordable price.

Full Breakdown: Transparent Labs RawSeries Betaine

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Where to Buy RawSeries Betaine
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2. Now Foods Betaine HCl

Now-Foods-Betaine-HCl

NOW Foods Betaine HCl is a betaine HCl supplement that comes in the form of a capsule. It also stacks betaine with the enzyme pepsin.

Highlights:

  • Affordable
  • Quality betaine dosage
  • Stacked with digestive enzyme pepsin

What’s in it:

  • 648 mg betaine HCL
  • 150 mg pepsin enzyme

Who makes it: NOW Foods is a natural supplement producer that manufactures top quality all natural dietary supplements. They have been in the industry since 1968 and are one of the well respected brands amongst consumers and other producers. They are committed to sustainability, transparency, and promoting healthy living. They are considered one of the pioneers of the health foods industry.

Bottom line: This betaine pill is manufactured by a very reliable company that has been in the natural supplement industry since 1968. If you are looking for a good product with effective betaine dosage, this may be the product for you.

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Where to Buy NOW Betaine HCl
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3. BulkSupplements Pure Betaine Anhydrous

BulkSupplements-Pure-Betaine-Anhydrous

BulkSupplements Pure Betaine Anhydrous is a betaine powder that is free of sugar, soy, dairy, yeast, gluten, or any other additives. This is one of the better betaine supplements on the market and allows you the ability to customize your betaine dosage.

It functions as a great workout supplement, and can be used as a pre workout, intra workout, or post workout supplement depending on your needs. You can stack this supplement easily and it comes in a large quantity for a very affordable price.

Highlights:

  • Large quantity
  • Pure betaine anhydrous
  • Customizable betaine dosage

What’s in it:

  • 1500 mg betaine anhydrous

Who makes it: BulkSupplements is a bulk supplement ingredient distributor that offers pure supplement ingredients to both consumers and producers. They are essentially a supplement wholesaler. They are located in Henderson, Nevada, and they supply over 200 different pure nutritional supplement ingredients in bulk at great prices. Their facilities are GMP certified, and they are also registered with the FDA.

Bottom line: BulkSupplements Betaine Anhydrous is a strong betaine supplement that comes in a large quantity at a very affordable price. It is one of the best betaine products on the market due to its high quality, purity, potency, and price. This is a great choice for serious athletes looking to redeem the benefits of betaine.

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Where to Buy BulkSupplements Pure Betaine
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4. Doctor’s Best Betaine HCI

Doctors-Best-Betaine-HCI

Doctor’s Best Betaine HCl provides an effective dose of 650 mg betaine HCl per betaine pill at a worthy price.

Highlights:

  • Affordable
  • Utilizes pepsin enzyme and gentian root

Drawbacks:

  • Efficacy may be lower than alternatives

What’s in it:

  • 650 mg betaine anhydrous
  • 25 mg pepsin
  • 20 mg gentian

Who makes it: Doctor’s Best is a dietary supplement brand that was founded by a physician in 1990 with the goal of helping others to improve their health. They offer more than 200 different products and use mostly branded ingredients that have been researched and tested for quality and efficacy. Their manufacturing facilities are all GMP certified, and they are committed to transparency with their products through education and communication.

Bottom line: This is a good betaine supplement for those who are looking for added digestive support ingredients. It offers an effective betaine dosage at an affordable price from a reliable manufacturer. However, there is some contention among consumers that it is not as potent as some alternative brands.

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Where to Buy Doctor’s Best Betaine
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5. Nutricost Betaine Anhydrous Trimethylglycine

Nutricost-Betaine-Anhydrous-Trimethylglycine

Nutricost Betaine Anhydrous Trimethylglycine is a betaine powder supplement that is made in the USA and is intended for use as a dietary supplement or an athletic supplement. It’s powdered form allows you to customize your betaine dosage which is preferable for athletes who may want to experiment with different dosages and stack ratios. It provides a massive quantity of betaine, with 333 servings of 1.5 grams in one container,  which is great for those who would be taking this supplement frequently.

Highlights:

  • Gluten free
  • Made in the USA
  • Huge quantity
  • Affordable

Drawbacks:

  • Includes fillers

What’s in it:

  • 5 g betaine anhydrous

Who makes it: Nutricost is a dietary supplement producer that supplies products such as amino acids, vitamins, protein, and both general health and workout supplements. Their products come backed with a 100% money back guarantee because they have that much confidence in their formulas. They claim to produce the purest forms of individual ingredients.

Bottom line: This is a great betaine supplement if you need a large quantity at an affordable price because it is an effective betaine supplement, and in one container you get 333 high betaine dosage servings. This number may be more if you choose to use a lower dose than the supplement facts recommend. However, this product does have additional ingredients silicon dioxide and calcium silicate.

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Where to Buy Nutricost Betaine
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6. Source Naturals – Betaine HCl

Source-Naturals---Betaine-HCl

Source Naturals – Betaine HCl is a betaine HCl and pepsin supplement that can be taken with a large meal to enhance digestion and absorption. Overall, it is a good betaine supplement.

Highlights:

  • Includes pepsin

Drawbacks:

  • Low quantity
  • More fillers

What’s in it:

  • 650 mg betaine HCl
  • 165 mg pepsin

Who makes it: Source Naturals is a natural supplement producer that specializes in vitamins and herbals. They are self proclaimed leaders of the wellness revolution. Created in 1982 by Ira Goldberg with the idea of creating products that maintain well being and enhance life, they now are one of the biggest companies in the industry. They actually pioneered the idea of combining nutraceuticals, herbs, and many different nutrients into one supplement, which is a common practice today.

Bottom line: This is a powerful betaine supplement that can be purchased at a reasonable price and is made by a reliable company. It is a great choice for someone who has never tried betaine HCl before and wants to test the waters. However, it does come in a low quantity and it uses more fillers than some other alternatives. It may not be the best choice for someone who knows that they will be using a lot of betaine.

7. Thorne Research – Betaine HCL

Thorne-Research---Betaine-HCL

Thorne Research – Betaine HCl is intended as a digestive support and offers betaine HCl and the enzyme pepsin in capsule form. It is entirely free from GMOs, soy, dairy, egg, peanuts, yeast, magnesium stearate, binders, coatings, artificial colors, flavors, or sweeteners.

Highlights:

  • Does not include many allergens
  • No GMOs
  • Includes pepsin to enhance digestion

Drawbacks:

  • Lower dose per capsule
  • Pricier than alternatives

What’s in it:

  • 04 g betaine HCl
  • 40 mg pepsin

Who makes it: Thorne Research is a dietary supplement manufacturer that was first established in 1984 when they released their first product, ascorbic acid. It was founded in Seattle, Washington with the vision of helping others improve their health all around the world. They are now an internationally known dietary supplement brand that has been involved in research and programs to expand our health knowledge.

Bottom line: This is a good betaine supplement for those who are athletes or those who want to support their overall health. It is made by a reliable manufacturer and uses quality and effective ingredients. However, each capsule only has 502 grams of betaine, which is not recognized as an effective betaine dosage. It is also more expensive than some alternatives.

8. Country Life Betaine Hydrochloride

Country-Life-Betaine-Hydrochloride

Country Life Betaine Hydrochloride is a top betaine supplement that comes in tablet form and includes supporting enzymes pepsin, papain, and bromelain.

Highlights:

  • Includes supporting enzymes pepsin, papain, and bromelain
  • Affordable

Drawbacks:

  • Uses more fillers than alternatives
  • Calcium carbonate may reduce efficacy of HCl

What’s in it:

  • 1200 mg betaine HCl
  • 4 mg pepsin
  • 10 mg papain
  • 10 mg bromelain

Who makes it: Country Life is a health and wellness supplement producer that has been in the health foods industry for over 40 years. Since 1971, they have been passionate about providing customers with quality and purity in their products. They mainly produce vitamins, supplemental tablets, and gummies, and they also produce health products for children.

Bottom line: It is manufactured by a reliable company and it uses a quality betaine dosage, though it is on the lower end at 600 mg per tablet, with three supporting digestive enzymes. However is uses more fillers than alternatives.

9. Biotics Research Betaine

Biotics-Research-Betaine

Biotics Research Betaine is a betaine HCl supplement that is supported by the enzyme pepsin.

Highlights:

  • Betaine HCl supplement
  • Gluten and dairy free

Drawbacks:

  • Expensive
  • Low quantity

What’s in it:

  • 700 mg betaine HCl
  • 10 mg pepsin

Who makes it: Biotics Research Corporation is a nutritional supplement brand that is committing to using the best of science and nature to create nutritional supplements that are superior in quality and efficacy. They have been a leader in the industry for over 30 years and they have stuck to their mission the entire time. They strive to maintain excellent in nutritional science and produce high-quality and accessible health products.

Bottom line: Biotics Research Betaine is a powerful betaine supplement that includes HCl and pepsin, which are beneficial digestive aids. It provides all the betaine benefits you could ask for and it is manufactured by a reliable producer. However, it is much more expensive, and it comes in a lower quantity.

10. Pure Encapsulations – Betaine HCL/Pepsin

Pure-Encapsulations---Betaine-HCL

Pure Encapsulations – Betaine HCl/Pepsin is another good betaine supplement with digestive enzymes. It includes additionalsupports of the enzyme pepsin.

Highlights:

  • Hypoallergenic
  • Vegetarian

Drawbacks:

  • Low betaine dosage
  • More expensive than alternatives
  • Less effective

What’s in it:

  • 520 mg betaine HCl
  • 21 mg pepsin

Who makes it: Pure Encapsulations is a nutritional supplement producer that specializes in producing hypoallergenic products that are free from additives and fillers. Their products are research based and designed to provide the consumer with effective results that are desirable and predictable. Their products are some of the most pure supplements that come in capsule and tablet forms.

Bottom line: Overall, this is a good betaine supplement. However, it does include a lower betaine dosage than some of its competitors. It also costs more than many of its alternatives, and may be less effective.

Betaine Supplements Guide

This guide is all about betaine, and how supplementing with betaine can provide you health benefits both now and in your future.

What is Betaine?

It turns out that it is. Aging proves that. As you get older and continue to wear down your cells through energy production, consumption, and biochemical reactions that keep the process going. This results in reduced levels of certain compounds that facilitate these reactions, because they are constantly being used.

One of these compounds is an amino acid called betaine, which supports the health of your body throughout your life. As you age, the levels of betaine in your body decrease, which leaves you more vulnerable to cellular damage, toxification, and certain health conditions.

Betaine, also known as trimethylglycine (TMG), is an amino acid that is a derivative of the nutrient compound choline. Other names for betaine include betaine anhydrous, or trimethylglycine (TMG).  The combination of choline and the amino acid glycine can result in the formation of betaine. Its main function in the body is that of an osmolyte, which means it protects cells, proteins, and enzymes from environmental stress such as extreme temperatures, low water supplies, and high salinity.

Considered a “methyl donor,” it aids in liver function, detoxification, and healthy cellular function; and its most important function in the body is to help the body process fats. It also is involved in the process of producing carnitine in the body, which is an amino acid that plays a role in energy production.

Homocysteine is an amino acid that most people obtain from eating meats. High levels of homocysteine are linked to early development of heart disease, renal disease, and low levels of vitamins B6, B12, and folate.

Betaine can be found naturally in shellfish, spinach, beets, broccoli, and grains. It is naturally present in many wheat products.

Benefits of Betaine

Betaine is a methyl donor and an osmolyte, which means it offers many different health benefits as a dietary supplement. A methyl donor donates a methyl group (one carbon connected to three hydrogen atoms, CH3) which kickstarts a methylation reaction, whereas removing a methyl group stops a reaction. There are hundreds of these reactions that occur throughout the body, and they can result in the detoxification reactions, as well as the production of serotonin and melatonin.

As an osmolyte, betaine protects the health and integrity of your cells. An osmolyte is a compound that affects osmosis, which is a cellular process in which a solvent tends to pass through a semipermeable membrane from a more concentrated solution to a less concentrated solution, equalizing the solutions on either side. Osmolytes are solvents in the solution, and they help maintain cell volume and balancing of fluids.

You can check out other benefits of betaine here.

Who Can Benefit from Betaine?

  • Athletes – Betaine may help enhance athletic performance. It can be used in preworkout and postworkout supplements to enhance muscle strength and power, as well as support a lean body composition. It does this through the methylation of homocysteine, which forms methionine. Methionine is an important biochemical component to the synthesis of creatine. This extra methionine production also increases protein synthesis in a process known as translation. A study at the University of Connecticut found that athletes that take 1.25 grams of betaine twice a day increased their muscle strength by 25%, and muscle power by 20%.
  • Those with Homocystinuria Homocystinuria is a genetic condition in which the body is unable to process certain amino acids and is caused by a mutation in the CBS, MTHFR, MTR, MTRR, and MMADHC genes. Homocystinuria disrupts the process of converting homocysteine into methionine, and results in increased levels of homocysteine in the blood which can harm health. Betaine is FDA approved for homocystinuria.

How to Take Betaine

Betaine dosages vary on your purposes and/or health conditions. You should consult a doctor to determine the right dosage regimen for you. If you are taking it as a dietary supplement, generally around 650 mg is an effective dose, but betaine dosages may range.

There are two types of betaine: Betaine HCL and betaine and betaine anhydrous. Betaine HCL should not be taken on an empty stomach because of its HCL attachment. Betaine anhydrous may be taken on an empty stomach.

Betaine Stacking

Betaine is a very stackable supplement and complements many other supplements to produce desired effects for athletes. Here are some of the best betaine stacks:

  • Betaine, Whey Protein, and Creatine – This stack works together to help the body break down proteins and absorb them. It also supports lean muscle growth and enhanced athletic performance.
  • Betaine, Creatine, and Digestive Enzymes – This stack is really beneficial when consuming a large meal. It helps to break down foods, absorb them, and utilize the nutrients. It is perfect for an endurance athlete that needs to load up on nutrients.
  • Betaine, Creatine, BCAAS, Citrulline, Glutamine – This is a common mix that is used as a powerful intra workout supplement. All of these amino acids work together to support muscle energy, recovery, and growth.

Are There Any Side Effects?

Betaine may cause gastrointestinal side effects such as bloating, nausea, diarrhea, and stomach upset. These side effects are more common with betaine HCL because of the hydrochloride attached to it. In general, if used correctly betaine should not cause too many unwanted side effects.

What to Look for in a Good Betaine Product

When searching for a top betaine supplement, you should be aware of your personal purposes for the supplement. If you are taking betaine for its digestive benefits, you should make sure that you get a betaine HCL supplement rather than a betaine anhydrous supplement. If you want more freedom to take your betaine supplement with or without food, you should make sure you get a betaine anhydrous supplement.

You should also evaluate the betaine dosage that the supplement provides. Generally, an effective betaine dosage is accepted to be about 650 mg or more. While you are checking out the supplement facts, check the other ingredients. The less fillers the better. If you are a vegetarian, there are vegetarian betaine supplements available and you should ensure that the label explicitly states that it is a vegetarian product.

Besides what is in the supplement, you also need to think about who made the supplement and how much it costs. A reliable manufacturer is an important component in a good betaine supplement. You can identify a reliable and transparent producer by doing a little research on their company. Generally, the best brands will say that they are certified or registered through some sort of reliable third party, such as the FDA or they will have a GMP certification. When evaluating costs of the product, think about quality and quantity in comparison to other products. Look for the best product at a fair price!

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Austin Meadows

Written by Austin Meadows

Austin Meadows is an independent writer and consultant specializing in health and wellness topics. With more than 7 years of experience writing in the natural health industry, Austin strives to deliver accurate, concise and research based information to his readers. You can connect with him on LinkedIn.