Best Grape Seed Extract Supplements – Top 10 Brands Ranked

Jump Ahead to the Top 10 Grape Seed Extracts

What is Grape Seed Extract?

As the name suggests, grape seed extract is a concentrated extract derived from grape seeds. Grape seeds are naturally very rich in antioxidants, which help prevent cell damage caused by free radicals. Grape seed is also rich in proanthocyanidins and polyphenols, two classes of potent flavonoid antioxidants that may have beneficial effects on the human body.

Marketers of grape seed extract supplements claim that the extract has far-spanning benefits, but many of these claims have not been definitively proven in clinical trials. The extract does show promise, however, in enhancing blood flow, reducing blood pressure, and providing many of the benefits associated with antioxidants.

Grape Seed Extract Uses

While manufacturers claim a huge range of potential grape seed extract benefits, the most studied effects of the compound include:

  • Antioxidant – one indisputable fact about grape seed extract is that it is very rich in antioxidants. Hundreds of clinical trials have looked at the effects of antioxidants on the human body, and the results are mostly positive. The benefits of antioxidants can include reducing your risk of certain cancers and Alzheimer’s disease, and even reducing age-related cognitive decline. Antioxidants may also be beneficial for cardiovascular health and immunity. With that said, antioxidants are typically most beneficial when obtained through the diet, rather than supplements.
  • Blood Pressure – grape seed extract given at standard doses may help to reduce blood pressure, as confirmed by a meta-analysis of several randomized controlled clinical trials. The reduction was relatively low, but it was noted that the majority of participants did see a drop in blood pressure levels after supplementing with grape seed extract.
  • Cognitive Function – it is possible that grape seed extract may be beneficial to cognitive function, particularly in older adults. Several studies have found promising results in the effects of grape seed extract on cognitive decline in Alzheimer’s patients, which leads many to believe the extract may be beneficial for maintaining cognitive function. With that said, current studies have only looked at patients with Alzheimer’s disease, so it’s unclear whether the extract would be beneficial to healthy individuals.
  • Bone Strength – the combination of grape seed extract and calcium may have a beneficial effect on bone formation, according to a 2005 study conducted on rats. This was an animal study, so human clinical trials are needed to confirm results.
  • Wound Healing – clinical trials conducted on mice have shown that grape seed extract has the potential to increase the speed of wound healing. However, this was an animal study, and looked at a topical application of the extract, which has not been studied in humans.

How to Take Grape Seed Extract

Grape seed extract typically comes in capsules, generally in doses between 100mg and 300mg. Some supplements offer stronger doses of up to 600mg.

Some products are offered in bulk, simply giving you a bag of loose powder. In these cases, you can mix the measure out a dose and mix it into water or food or put it in capsules yourself.

While there is no official recommended doses, studies looking at grape seed extract have used dosages between 150 and 300mg. Doses up to 600mg have been observed in clinical trials, with no side effects reported.

It’s best to follow the manufacturer instructions on the product you’re using. Grape seed extract should typically be taken with food for best results.

Grape Seed Extract Side Effects and Precautions

Grape seed extract does not typically cause side effects. Some unwanted effects are possible, including headache, nausea, itchy scalp and dizziness. If side effects occur, stop taking the supplement.

Those who are allergic to grapes should avoid grape seed extract. Additionally, those with bleeding disorders or high blood pressure should seek the advice of a doctor before taking these extracts.

Due to a lack of definitive clinical safety evidence, pregnant women are advised not to take grape seed extract. Children should also avoid the supplement, unless otherwise instructed by a medical professional.

It is possible that grape seed extract may interact with certain medications, including blood thinners, cancer treatments, painkillers, and certain heart medicines. Consult your doctor if you are taking any medicines regularly.

What to Look for in a Good Grape Seed Extract Supplement

A good grape seed supplement will contain somewhere between 100mg and 600mg of the extract in each serving. You can choose how strong of a supplement you want depending on your needs and goals.

It should be standardized to contain between 90 and 95% polyphenols, the main active ingredient in these extracts.

Ideally it should also be made by a well-known, reputable company that has a reputation for quality products. Lastly, it should be affordable and provide good value to the consumer.

Top 10 Grape Seed Extracts Compared

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1. BulkSupplements Pure Grape Seed Extract Powder

BulkSupplements Pure Grape Seed Extract Powder

This is a simple, pure and effective supplement from a great company. It contains pure grape seed extract powder, and NOTHING else. It’s packed in a no-frills, simple bulk bag, and it’s very affordable. The bulk packaging allows you to save a lot of money and customize your own doses according to your needs and preferences.

Specs

  • Variable dose – you can measure your own serving size
  • Can be put into capsules or mixed into beverages
  • Clean and pure
  • No fillers – NO ingredients besides grape seed
  • Lab tested for purity
  • Very affordable
  • Excellent reviews

Who Makes It?

BulkSupplements is a Nevada-based company that specializes in wholesale supplements and ingredients. They save their customers a ton of money because they skip the fancy packaging and marketing campaigns to stick with what they do best: making excellent products.

Bottom Line

This is the best grape seed extract on the market. It’s very affordable, and there’s no fluff, fillers or additives. You will have to measure out your own doses, but this allows for a lot more customization than grape seed extract pills offer.

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2. NOW Foods Grape Seed Extract

NOW Foods Grape Seed Extract

This is a top grape seed extract supplement with 100mg of standardized extract in each serving. For those who prefer pre-packaged capsules for convenience, this is the best grape seed supplement available.

Specs

  • 100mg extract per serving
  • 90% polyphenols
  • Standardized extract for consistency
  • Non-GMO
  • Very affordable
  • Excellent reviews

Who Makes It?

This is made by NOW Foods, which is one of the largest brands in the health industry. They offer more than 1,400 products, ranging from health supplements to vitamins to health foods. They are committed to quality and are a brand you can trust.

Bottom Line

If you want the best grape seed extract pills, this is the product for you! This product offers a simple yet effective formula and is available at a very affordable price – from a company with an excellent reputation.

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3. Olympian Labs Grape Seed Supplement

Olympian Labs Grape Seed Supplement

This is a good grape seed extract product offering 600mg per capsule. It’s formulated to be free of common allergens, and its vegan friendly.

Specs

  • 600mg extract per serving
  • 95% polyphenols
  • Allergen free
  • Vegan friendly
  • Non-GMO
  • Manufacturer follows Good Manufacturing Practices
  • Made in the USA

Who Makes It?

Olympian Labs is based in Phoenix, Arizona and produces a wide range of health products. They were established in 1992 and focus primarily on helping athletes achieve their fitness goals.

Bottom Line

This is an excellent product at a great price. It’s made in the USA, and free of most common allergens. It’s also a strong grape seed extract due to the high dosage amount.

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4. GNC Herbal Plus Grape Seed Extract

GNC Herbal Plus Grape Seed Extract

This is a well rated grape seed supplement from a household name brand. It offers 300mg per serving and is standardized to 95% polyphenols.

Specs

  • 300mg extract per serving
  • Standardized to 95% polyphenols
  • Vegetarian/vegan friendly
  • Great reviews
  • A bit expensive

Who Makes It?

GNC is a brand that most people will recognize. Their stores are present in malls and shopping centers throughout the world. They sell a wide range of health and wellness products through retail stores and digital sales.

Bottom Line

This is a great product, and a top recommendation for our readers. The only downside is that it’s a bit on the expensive side compared to our top recommendations.

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5. Nature’s Way Grape Seed

Nature's Way Grape Seed

This is a standardized grape seed extract product with 95% polyphenols. It’s made by a very well known, trustworthy company.

Specs

  • 100mg extract per serving
  • 95% polyphenols
  • Standardized for consistency
  • Non-GMO Project Verified
  • Vegetarian capsules
  • Contains magnesium stearate

Who Makes It?

Nature’s Way is a brand that you can find on store shelves worldwide. They partner with the Non-GMO Project and Tru-ID, which individually test all their products for GMO status and authenticity of herbal products.

Bottom Line

This is a great product, but it does contain magnesium stearate which some people prefer to avoid.

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6. Source Naturals Proanthodyn Grape Seed Extract

Source Naturals Proanthodyn Grape Seed Extract

This is a simple and straightforward grape seed supplement made by a trustworthy company. It’s well reviewed and hypoallergenic.

Specs

  • 100mg extract per serving
  • 95% polyphenols
  • 20mg calcium per serving
  • Hypoallergenic: free of gluten, yeast, dairy, egg and most common allergens
  • Expensive

Who Makes It?

Source Naturals is a health company that aims to help individuals reach their potential for optimal health. They were founded in 1982.

Bottom Line

This is a good product offering the standard dosage amount, with a small amount of added calcium (the calcium dosage is quite low, so it’s unlikely to provide much benefit). It’s on the expensive side, however.

7. Purethentic Naturals Grape Seed Extract

Purethentic Naturals Grape Seed Extract

This is a powerful grape seed extract supplement with 300mg in each serving.

Specs

  • 300mg grape seed extract per serving
  • Standardized to 95% polyphenols
  • Maximum potency
  • GMO free
  • Good reviews
  • Expensive

Who Makes It?

Purethentic Naturals is a small but growing health supplement company that primarily sells their goods through online retailers.

Bottom Line

This is a potent option with triple the average dose found in most of these supplements. It’s rather expensive, though.

8. Jazzee Naturals Grape Seed Extract

Jazzee Naturals Grape Seed Extract

This is a strong grape seed supplement with a whopping 400mg dose per capsule.

Specs

  • 400mg extract per capsule
  • Standardized to 95% polyphenols
  • Made in the USA
  • Dose may be more than necessary for some

Who Makes It?

Jazzee Naturals is a small retailer and manufacturer of consumer health supplements. They sell mostly online at Amazon.com

Bottom Line

If you want a very strong supplement, this might be a good choice – but honestly, the dosage might be higher than necessary for many applications.

9. Herbal Secrets Grape Seed Extract

Herbal Secrets Grapeseed Extract

This is a potent grapeseed extract supplement with 400mg per serving.

Specs

  • 400mg extract per capsule
  • 95% polyphenolsg
  • Made in the USA
  • 3rd party tested
  • Follows Good Manufacturing Practice protocols
  • Huge dose may be unnecessary

Who Makes It?

Herbal Secrets is a division of Amazing Nutrition, a large health supplement company based in the USA.

Bottom Line

This is a good product, but the 400mg dose may be more than necessary.

10. BlueBonnet Super Fruit Grape Seed Extract

BlueBonnet Super Fruit Grape Seed Extract

This is a simple and effective product offering the standard dosage of grapeseed extract.

Specs

  • 100mg extract per serving
  • 95% polyphenols
  • Gluten and soy free
  • Vegan
  • Very expensive

Who Makes It?

Bluebonnet Nutrition is a large-scale supplement firm that was founded in 1991.

Bottom Line

This is a good product, but it’s extremely expensive on a per-dose perspective. There are better products out there for the price.

Austin Meadows

Written by Austin Meadows

Austin Meadows is an independent writer and consultant specializing in health and wellness topics. With more than 7 years of experience writing in the natural health industry, Austin strives to deliver accurate, concise and researched based information to his readers. You can find more of Austin's work at Olympic-Creative.com, or connect with him on LinkedIn.