Best Lysine Supplements Ranked for 2018 (Top 10 Brands)

This is our official list of the best lysine supplements on the market. These 10 brands have the best feedback from users and the highest reviews online.

Top 10 Lysine Products Compared

Heads up, there are affiliate links in this article, so if you buy something, we get a cut of the sale.


1. NOW Foods L-Lysine

Best Lysine Supplements to buy

NOW L-Lysine is a great lysine supplement. It provides a healthy dose of L-lysine 1000 mg per serving. This product is available in a 100 or 200 count bottle. The supplement is in capsule form.

Specs

  • Provides 1000 mg of L-lysine per serving
  • Serving size in one capsule
  • Value for money
  • Vegan-friendly

Who Makes It?

NOW Foods is one of the most established companies in the industry, with a history dating back to 1968. They are a trusted, reputable name in the health product world, and today produce more than 1,400 different products.

Bottom Line

If you’re looking for an excellent lysine supplement this is one of the best. It has a powerful strength of 1000 mg per cap and is made with vegetarian capsules. The capsules are quite large, so this supplement may not be suitable if you have difficulty swallowing tablets. This product is available at a very reasonable price.

ⓘ If you buy something using the link below, we get a small commission.

Where to Buy NOW Foods L-Lysine
amazon-logo-newer

2. Solgar L-Lysine

solgar-l-lysine

Solgar L-Lysine provides 1000 mg of L-lysine per serving. Each serving size is one tablet, which may be taken once or twice daily, with or without meals. This supplement is available in the sizes: 50, 100, and 250 count.

Specs

  • Provides 1000 mg of L-lysine per serving
  • L-lysine HCL free form
  • No common allergens
  • Gluten-free
  • Contains fillers

Who Makes It?

Solgar is a U.S.-based company that has been manufacturing quality nutritional supplements since 1947. The team is dedicated to developing a high-quality range of science-based supplements to support total health. Solgar manufactures a wide range of dietary supplements at affordable prices.

Bottom Line

This is another top lysine supplement. Solgar is a well-known and well-respected brand. These supplements are strong, vegan, allergen and gluten-free and they are made with L-lysine HCL free form.

ⓘ If you buy something using the link below, we get a small commission.

Where to Buy Solgar L-Lysine
amazon-logo-newer

3. Source Naturals L-Lysine

source-naturals-l-lysine

Source Naturals Free-Form L-Lysine is an effective lysine supplement that provides 500 mg of L-lysine HCL per serving. You can take a serving once or twice daily. This supplement is available in bottles of 250 tablets.

Specs

  • 500 mg of L-lysine per serving
  • No sugar
  • Vegan-friendly
  • No artificial colors of flavors
  • No common allergens

Who Makes It?

Source Naturals is large US-based supplement manufacturer. They use a unique Bio-Alignment™ strategy, which is intended to make their products easily absorbed and highly effective.

Bottom Line

These are effective L-lysine pills which are a slightly lower dose that many other supplements of this kind, giving you the opportunity to regulate your dose as you wish. This product is vegan and allergen and additive free. Unfortunately, it does contain fillers.

ⓘ If you buy something using the link below, we get a small commission.

Where to Buy Source Naturals L-Lysine
amazon-logo-newer

4. Solaray L-Lysine

solaray-l-lysine

Solaray Free-Form L-Lysine provides 500 mg of L-lysine HCL per serving. Each serving size is one capsule. The bottle contains 120 capsules.

Specs

  • Provides 500 mg of L-lysine HCL per serving
  • Not suitable for vegetarians
  • No artificial additives
  • Good value
  • Contains fillers

Who Makes It?

Solaray is a trusted brand and part of the Nutraceutical company. It started back in 1973, and today is trusted worldwide.

Bottom Line

If you’re not vegetarian, these are good lysine pills. They are free from additives and gluten. They do however, contain fillers.

ⓘ If you buy something using the link below, we get a small commission.

Where to Buy Solaray L-Lysine
amazon-logo-newer

5. Country Life L-Lysine

country-life-l-lysine

Country Life L-Lysine provides 1000 mg of lysine per serving. Each serving is one tablet. The bottle has 250 tablets.

Specs

  • 1000 mg of lysine per serving
  • Gluten-free
  • Vegan
  • No common allergens
  • Includes vitamin B6

Who Makes It?

Country Life is a U.S.- based dietary supplement manufacturer that was founded in 1971. They have been a pioneer in the natural health industry for more than 40 years and are well-respected for their products.

Bottom Line

This is one of the best L-lysine supplements on the market. In addition to packing a powerful 100 mg of L-lysine HCL, it is gluten and additive free, and contains no fillers or common allergens.

ⓘ If you buy something using the link below, we get a small commission.

Where to Buy Country Life L-Lysine
amazon-logo-newer

6. Spring Valley L-Lysine

spring-valley-l-lysine

Each capsule of Spring Valley L-Lysine contains 1000 mg of lysine. It is one tablet per serving.

Specs

  • 1000 mg of lysine per serving
  • No gluten
  • No GMO
  • No common allergens
  • No artificial preservatives

Who Makes It?

Spring Valley is a small supplement retailer that mostly markets their products online.

Bottom Line

This is a good supplement with a high dose. Keep in mind that there have been a number of complains about some of this company’s products not containing the ingredients as stated on the bottle.

7. Pure Encapsulations L-Lysine

pure-encapsulations-l-lysine

Pure Encapsulations L-Lysine provides 500 mg per serving. Serving size is one tablet.

Specs

  • Provides 500 mg per serving
  • Vegan-friendly
  • Hypoallergenic ingredients
  • Gluten -free
  • Contains fillers

Who Makes It?

Pure Encapsulations is a manufacturer of nutritional supplements. They design research-based formulas and use hypoallergenic ingredients.

Bottom Line

This is a better than average L-lysine supplement made with quality ingredients.

8. Thorne Research L-Lysine

thorne-research-l-lysine

Thorne Research L-Lysine tablets each contain 500 mg of L-lysine as lysine monohydrochloride. Each serving size is one tablet. This supplement is available in a 60-count bottle.

Specs

  • 500 mg of L-lysine per serving
  • No common allergens
  • No gluten
  • Pure ingredients
  • Good price

Who Makes It?

Thorne supplements use only pure, DNA-tested ingredients. They never include artificial sweeteners, colors or preservatives, dairy products, common allergens, or irradiated botanicals.

Bottom Line

These are effective L-lysine pills, with no unnecessary additives, offered at an affordable price.

9. Superior Labs L-Lysine

superior-labs-l-lysine

Superior Labs L-Lysine provides 500 mg of lysine HCL per serving. Serving size is one tablet. The bottle contains 120 capsules.

Specs

  • Provides 500 mg of lysine HCL per serving
  • Vegan-friendly
  • Good value
  • Contains fillers

Who Makes It?

Superior Labs Supplements are a U.S.-based company that have been in production for more than a decade. They have a 100% money back guarantee if you are not satisfied with their products.

Bottom Line

These are good lysine pills at an affordable price. They are free from common allergens and made with non-GMO ingredients.

10. Designs For Health L-Lysine

designs-for-health-l-lysine

Designs For Health L-Lysine provides 1500 mg of lysine HCL per serving. Serving size is two tablets. The bottle contains 60 capsules.

Specs

  • Provides 1500 mg of lysine HCL per serving
  • No common allergens
  • Non-GMO
  • Vegan-friendly
  • Gluten-free

Who Makes It?

Designs For Health is a professional brand of dietary supplements formulated on science-based research. The company was founded in 1989 by a team of nutritionists.

Bottom Line

This is a good lysine supplement. It is offered at a very affordable price and the pills are gluten-free and contain no common allergens.

Lysine Supplements Guide

What is Lysine?

Lysine is an amino acid. Amino acids are the building blocks of protein. There are three types of amino acid; non-essential, semi-essential, and essential. A large percentage of the body’s cells, tissues, and muscles are made from amino acids.

In addition to providing cells with their structure, amino acids carry out several important bodily functions, such as transporting and storing nutrients. Amino acids also contribute to the healthy functioning of the organs, arteries, tendons, and glands. They are also vital for tissue repair and wound healing and the removal of waste from the body via metabolism.

Lysine is one of the nine essential amino acids for your body. The other eight are methionine, threonine, valine, tryptophan, phenylalanine, isoleucine, histidine, and leucine. Essential amino acids cannot be made by the body, so they must be sourced from food or nutritional supplements. Food sources of lysine include:

  • Soy milk
  • Lentils
  • Pumpkin seeds
  • Quinoa
  • Pistachios
  • Tempeh
  • Shrimp
  • Chicken
  • Pork
  • Tuna
  • Cheese

Lysine’s bioavailability from foods can be affected by certain cooking methods. For example, cooking in combination with sugars and dry cooking at high temperatures can reduce lysine’s bioavailability.

Lysine was discovered in 1889 by a scientist known as Drechsel. Originally, he isolated lysine from milk protein. The exact structure of the amino acid was recorded three years later. The molecule was completely synthesized in 1928.

Today, lysine is found in nutritional supplements, where it is commonly paired with vitamin C.

Uses & Benefits of Lysine

Potential lysine benefits include:

  • Collagen: Collagen is a form of protein. It is found in the skin and connective tissues where it helps form the tissue’s structure. It helps to give skin its elasticity.According to this study, lysine can help with the formation of collagen. It can also help reduce the breakdown and excretion of collagen. More research is needed.
  • Herpes simplex: More commonly known as cold sores, herpes simplex causes fluid-filled blisters to appear on the lips and around the mouth. A 2005 study published in Alternative Medicine Review, showed that lysine, in combination with herbs and zinc, was able to clear symptoms of herpes simplex within three to six days. More research is needed.
  • Diabetes: Lysine has been shown to improve the function of glycated lysozyme, which makes it a good therapeutic aid in the treatment of type 2 diabetes. It may help to reduce the risk of infection in sufferers of this disease. More research is needed.
  • Insulin: A 2009 study published in the American Journal of Clinical Nutrition showed that taking a combination of lysine and glucose can help increase insulin production more than taking glucose alone. Lysine may also be able to decrease fasting glucose levels. More research is needed.
  • Heart health: LDL cholesterol (low-density) can build up in the arteries causing blockages, hardening, and blood clots. These symptoms increase the risk of heart attack or stroke. Lysine triggers the production of carnitine, which breaks down LDL cholesterol.
  • Pancreas: Lysine supplementation may reduce the risk of inflammation of the pancreas, particularly after a pancreatic illness or injury.
  • Bone strength: Calcium deficiency can result in age-related bone loss and osteoporosis. A 1992 study, published in Nutrition, showed that lysine may help reduce the symptoms of osteoporosis. More research is needed.
  • Digestive health: A 2015 study, published in the Journal of Agricultural and Food Chemistry, showed that a form of lysine known as poly-L-lysine, may help to support gut health. More research is needed.

Some lysine supplement manufacturers claim that lysine is also beneficial for hair loss. There is no evidence to support this claim.

How to Take Lysine

When it comes to lysine supplement dosage, there is no FDA approved recommended daily amount. However, the suggested lysine dosage is 1000-2000 mg per day. Even if you have a diet that is high in lysine, taking this amount daily is typically safe. Any dose under 8000 mg is not considered to be at risk of causing toxicity.

If you are taking a lysine supplement, then you should avoid taking an arginine supplement or eating foods which are rich in arginine at the same time. This is because arginine can reduce the effectiveness of lysine supplementation. Foods containing arginine include dairy, chocolate, and nuts.

You should also avoid taking large amounts of calcium with lysine supplementation as lysine can increase your body’s absorption of calcium. You should also reduce calcium-rich foods in your diet.

Lysine Side Effects and Precautions

Although lysine supplementation is generally regarded as safe, possible side effects include:

  • Abdominal pain
  • Diarrhea
  • Nausea
  • Inflammation or the kidneys
  • Kidney failure

If you experience any of these side effects, you should stop taking the lysine supplement and seek medical advice.

There are currently no reports of lysine causing any interactions with other medications or herbal supplements.

You should take lysine as directed on the package. You should not use a combination of different formulations of lysine at the same time (such as liquids and tablets). Doing so may increase the risk of an adverse reaction.

You should avoid taking lysine if you are pregnant or breastfeeding.

What to Look for in a Good Lysine Supplement

There are several forms of lysine including:

  • L-lysine
  • Lysine HCl
  • Lysine oxidase
  • Lysine succinate
  • Lysine clonixinate
  • Lysine acetylsalicylate
  • Powdered lysine

The best lysine pills will contain L-lysine and no additives or fillers. A good lysine supplement should not contain soy or other common allergens such as dairy products, nuts, yeast, and seafood. It should also be gluten and GMO-free.

The best supplements are made in the U.S. in adherence to strict, FDA approved manufacturing practices. Be sure that you are buying a pharmaceutical grade lysine supplement. Some supplements’ capsules are large. If you have difficulty swallowing pills, you may want to look for a lysine supplement which has smaller, lower dose tablets.

Remember, not all supplements are suitable for vegans or vegetarians. If a supplement contains gelatin, it is not vegetarian.

Austin Meadows

Written by Austin Meadows

Austin Meadows is an independent writer and consultant specializing in health and wellness topics. With more than 7 years of experience writing in the natural health industry, Austin strives to deliver accurate, concise and researched based information to his readers. You can find more of Austin's work at Olympic-Creative.com, or connect with him on LinkedIn.