Best PQQ Supplements Ranked for 2018 – Top 10 Brands

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What is PQQ?

Termed by some manufacturers as “the other CoQ10,” pyrroloquinoline quinone (PQQ), is a quinone molecule which is also a redox cofactor – this means it has antioxidant effects, after which it returns to its previous active form. It is capable of cycling through this process several thousands of times before it is used up. In this, it is unique.

PQQ was discovered in 1979 by J.G. Hauge. It was the third redox cofactor to be discovered. Redox cofactors are a vital component of the human metabolic process. PPQ’s role is to trigger cell signal pathways involved in the metabolism of energy, helping the body transport energy obtained from food.

PQQ also has a number of other important roles within the body’s cells. However, one that is considered high priority is its role in the development of mitochondria. Mitochondria are tiny specialized structures that reside in each of the body’s cells. They are responsible for powering the cell, rather like a battery. PQQ not only activates the growth of mitochondria, but it also protects them from oxidative stress.

The discovery of PQQ led to many channels of clinical research, including the biological significance of PQQ, investigations on other enzymes which interact with these molecules, and how PQQ can be used in the treatment of disease.

As well as the human body, PQQ can also be found in soil and foods such as kiwifruit, bananas, cabbage, potatoes, carrots, tofu, spinach, parsley, and egg yolk. It is also found in skim milk, green tea, oolong tea, and sake.

Uses & Benefits of PQQ

A considerable amount of research has been conducted on pyrroloquinoline quinone benefits.

  • Metabolism: It was already known that dietary pyrroloquinoline quinone has effects on energy-related metabolism and brain functions in animals. In a cross-over study published in 2013 in the Journal of Nutritional Biochemistry, the effects of dietary pyrroloquinoline quinone were tested on humans. In this study, ten subjects were given PQQ in a drink in either a single dose of 0.2 mg PQQ/kg or 0.3 mg PQQ/kg. Changes in PQQ levels in urine and plasma were measured, as were changes in antioxidant potential. The results showed that supplemental PQQ has positive effects on inflammation and mitochondrial metabolism in humans.
  • Fatigue: A 2012 study published in Functional Foods in Health and Disease was designed to test the effects of pyrroloquinoline quinone on fatigue, stress, and quality of sleep. In the trial, 17 adult subjects were given 20 mg of pyrroloquinoline quinone each day for eight weeks. The results showed that PQQ improved sleep onset, quality of sleep, and reduced sleepiness on awakening. The same study also revealed some pain relief in the subjects.
  • Antioxidants: A preliminary animal study published in 2010 in the Journal of Biological Chemistry showed that pyrroloquinoline quinone may create new mitochondria and provide added protection from free radicals by increasing the internal production of antioxidants. More research is needed.
  • Memory: A 2008 animal study published in the Journal of Clinical Biochemical Nutrition, suggested that PQQ may prevent memory loss caused by oxidative stress. More research is needed.
  • Methylmercury toxicity: Methylmercury is a highly toxic form of mercury that is formed when bacteria reacts with mercury in plants, water, or soil. It was once used as a preservative for animal grain feed. It is still used in batteries, fluorescent lights, and polyvinyl chloride, which is used to make plastic pipes, sheeting, and flooring. Methylmercury poisoning can damage the brain and nervous system. A 2009 study published in Free Radical Research, showed that PQQ can offer protection against methylmercury toxicity.

Many PQQ supplement manufacturers claim that PQQ can help protect against Alzheimer’s and Parkinson’s, protect against stroke, help improve obesity and help protect the heart. There is no clinical evidence to support these claims.

How to Take PQQ

There is no standardized PQQ supplement dosage. However, based on trials, effective PQQ dosage could be as low as 2 mg. The suggested dosage for most pyrroloquinoline quinone dietary supplements is within the range on 20-40 mg.

PQQ Side Effects and Precautions

PQQ is generally considered safe when taken orally in the suggested doses for short periods of time. It is possible that taking high doses over PQQ over an extended period of time may cause damage to the liver and kidneys.

Because of the lack of available information, you should not take PQQ if you are pregnant or breastfeeding.

There is currently no available information about PQQ’s interaction with other drugs.

What to Look for in a Good PQQ Supplement

The best pyrroloquinoline quinone supplements should have a potency of around 20 mg. An effective pyrroloquinoline quinone should be non-GMO, free from common allergens, gluten, unnecessary fillers, and artificial additives. It should also be suitable for vegetarians and vegans.

Top 10 PQQ Products Compared

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1. Jarrow Formulas PQQ

Jarrow Formulas Pyrroloquinoline Quinone

Jarrow Formulas PQQ provides 20 mg of PQQ per serving. Serving size in one tablet. The bottle contains 30 capsules.

Specs

  • Provides 20 mg of PQQ per serving
  • Gluten-free
  • No common allergens
  • Not suitable for vegetarians
  • Contains fillers

Who Makes It?

Jarrow Formulas is based in Los Angeles, California that was founded in 1977. Today the company supplies dietary supplements worldwide. The Jarrow’s motto is “Superior Nutrition and Formulation,” and it maintains this ethos by providing a complete line of nutritional products, each of which are monitored for purity and potency.

Bottom Line

This is a good pyrroloquinoline quinone supplement. It is gluten-free and contains no common allergens. On the downside, the capsules are made with gelatin, so they are not suitable for strict vegans or vegetarians.

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2. Doctor’s Best PQQ

Doctor's Best PQQ Nutritional Supplement

Doctor’s Best PQQ provides 20 mg of PQQ per serving. Serving size in one tablet. The bottle contains 30 capsules.

Specs

  • Provides 20 mg of pyrroloquinoline quinone per serving
  • Non-GMO
  • Gluten-free
  • Soy-free
  • vegan

Who Makes It?

Doctor’s Best was started in 1990 by a group of medical practitioners. They currently produce more than 200 nutritional supplements, each made with science-based formulas. They are also made using proprietary ingredients, which are rigorously researched and tested for potency and purity. All Doctor’s Best products are manufactured following Good Manufacturing Practices specifications.

Bottom Line

This is one of the top PQQ supplements on the market. It has a good PQQ potency. Not only is it free from gluten, soy, and GMOs, but it is also vegan.

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Where to Get It
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3. Health Thru Nutrition PQQ

Health Thru Nutrition PQQ 20mg

Health Thru Nutrition PQQ provides 20 mg of PQQ per serving. Serving size in one tablet. The bottle contains 120 capsules.

Specs

  • Provides 20 mg of PQQ per serving
  • Contains 108 mg of calcium
  • Vegan
  • Contains fillers
  • Good price

Who Makes It?

Health Thru Nutrition have been manufacturing dietary supplements for more than 40 years. All of their formulas are based on clinical research and medical practices. Their aim is to provide the best nutrition products on the market. All their products are made in Good Manufacturing Practices certified facilities. They also use third-party testing for authenticity and purity of their ingredients.

Bottom Line

Health Thru Nutrition make effective PQQ pills. As well as 20 mg of pyrroloquinoline quinone, you get the added bonus of 108 mg of calcium. This supplement is good value for money, and it’s vegan.

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4. Life Extension PQQ Caps with BioPQQ

Life Extension PQQ Caps with BioPQQ

Life Extension PQQ Caps provide 10 mg of PQQ per serving. Serving size is one tablet. The bottle contains 30 capsules.

Specs

  • Provides 10 mg of PQQ per serving
  • Vegetarian
  • No common allergens
  • Gluten-free
  • Non-GMO

Who Makes It?

Life Extension has been a pioneer in cutting-edge medical research for more than 35 years. Not only do they produce high-quality nutritional supplements, they have also funded over $175 million for research into disease and anti-aging. This research is supported, in part, by sales of their dietary supplements. They claim that their advanced formulas are often 20-30 years ahead of current medical research.

Bottom Line

These are one of the best pyrroloquinoline quinone pills. They contain only 10 mg of PQQ, so this is a good choice if you haven’t tried the supplement before and you want to start with a low dose. They are also free of unwanted additives.

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Where to Get It
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5. Now Foods PQQ Energy Plus

Now-Foods-PQQ-Energy-Plus

NOW Foods PQQ Energy Plus provides 20 mg of PQQ per serving. Serving size in one tablet. The bottle contains 60 capsules.

Specs

  • Provides 20 mg of PQQ per serving
  • Non-GMO
  • Vegetarian
  • Gluten-free
  • Good price

Who Makes It?

NOW Foods was established in 1968 and is now one of the largest health supplement manufacturers in the world.

Bottom Line

These are powerful pyrroloquinoline quinone pills made by a respectable company. Each veggie capsule has 20 mg of PQQ and is gluten-free and non-GMO. This supplement is offered at a good price.

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6. Swanson PQQ

Swanson Pqq Pyrroloquinoline Quinone

Swanson PQQ provides 20 mg of PQQ per serving. Serving size in one tablet. The bottle contains 30 capsules.

Specs

  • Provides 20 mg of PQQ per serving
  • Vegan
  • Gluten-free
  • No common allergens
  • Contains fillers

Who Makes It?

Swanson Vitamins are based in Fargo, North Dakota. They were established in 1969, when their founder, who was diagnosed with arthritis, began looking for a natural supplement to ease his symptoms. When he succeeded, he became determined to share his knowledge with others and Swanson was born. Today, Swanson Health produces a wide range of vitamins, minerals, and herbal supplements.

Bottom Line

This is a strong PQQ supplement, made to Swanson’s usual high standards. It contains no gelatin, so it’s suitable for vegans and vegetarians. It’s also non-GMO, free of gluten and additives and artificial colors, flavors or sweeteners.

7. Relentless Improvement PQQ

Relentless Improvement PQQ 20mg

Relentless Improvement PQQ provides 20 mg of PQQ per serving. Serving size in one tablet. The bottle contains 60 capsules.

Specs

  • Provides 20 mg of PQQ per serving
  • Gluten-free
  • No fillers
  • Non-GMO
  • Good reviews

Who Makes It?

Relentless Improvement was established in 2005. They offer high-quality supplements at affordable prices. All their products are made and bottled in U.S.-based FDA registered, GMP facilities. They ship directly to the consumer. They also support community organizations such as the World Transhumanist Association, Betterhumans, and the Immortality Institute.

Bottom Line

These are powerful PQQ pills made by a reputable company.  They are made from quality ingredients with no common allergens, and no GMO content. This product is gluten-free and contains no unnecessary fillers.

8. Absorb Health PQQ

Absorb Health PQQ (Pyrroloquinoline Quinone)

Absorb Health PQQ provides 20 mg of PQQ per serving. Serving size in one tablet. The bottle contains 30 capsules.

Specs

  • Provides 20 mg of PQQ per serving
  • Gluten-free
  • Non-GMO
  • Vegan
  • No fillers

Who Makes It?

When his wife became ill in 2011, Josh Fulton began to research natural methods that could cure her sickness. During the course of his research, he realized that many natural dietary supplements could be brought to market at more affordable prices than were currently available. His passion to provide superior-quality supplements at affordable prices continues with Absorb Health.

Bottom Line

Another powerful pyrroloquinoline quinone supplement, this product is a great choice if you are vegetarian or vegan as this product contains no gelatin. It is also free from GMO, gluten and common allergens.

9. Element Nutraceuticals PQQ

Element Nutraceuticals PQQ

Element Nutraceuticals PQQ provides 20 mg of PQQ per serving. Serving size in one tablet. The bottle contains 150 capsules.

Specs

  • Provides 20 mg of PQQ per serving
  • Gluten-free
  • Non-GMO
  • Contains fillers
  • Good reviews

Who Makes It?

Element Nutraceuticals is a U.S. based company made up of a team of pro athletes. They produce a range of dietary supplements aimed at bodybuilders and athletes.

Bottom Line

This is a good PQQ supplement with no unwanted additives. Although it is marketed for bodybuilders and athletes, it is suitable for anyone.

10. Source Naturals PQQ Mind

Source Naturals PQQ Mind

Source Naturals PQQ Mind provides 20 mg of PQQ per serving. Serving size in one tablet. The bottle contains 60 capsules.

Specs

  • Provides 20 mg of PQQ per serving
  • Vegan
  • No common allergens
  • Gluten-free
  • No sugar

Who Makes It?

Source Naturals is a U.S.-based company that pledges an unfaltering commitment to exceptional standards of quality.

Bottom Line

Although a strong PQQ supplement, this is one of the more expensive brands on the market. However, it is good quality, and contains no unwanted or unnecessary ingredients.

Austin Meadows

Written by Austin Meadows

Austin Meadows is an independent writer and consultant specializing in health and wellness topics. With more than 7 years of experience writing in the natural health industry, Austin strives to deliver accurate, concise and researched based information to his readers. You can find more of Austin's work at Olympic-Creative.com, or connect with him on LinkedIn.