Best Serrapeptase Supplements – Top 10 Brands Ranked for 2018

Jump Ahead to the Best Serrapeptase Products

What is Serrapeptase?

Serrapeptase, or Serratio Peptidase, is a proteolytic enzyme (this means that it digests proteins) produced by the silkworm. It is found in silkworms’ intestines and is the chemical which allows the moth to dissolve the cocoon as it emerges. Serrapeptase was isolated from the silkworm Bombyx mori in the 1960s. Today, it is isolated and coated in tablet-form and is sold as a dietary supplement.

Uses & Benefits of Serrapeptase

Supplement manufacturers tout numerous serrapeptase benefits. Some are backed by clinical evidence, while others are less clear.

  • Inflammation: In a 1984 study published in Pharmatherapeutica, a trial was undertaken to assess the anti-inflammatory effects of serrapeptase.  Total of 174 patients underwent surgery to relieve the buildup of pus between the lungs and the chest wall. A percentage of the patients were given 10 mg of serrapeptase three times on the day prior to surgery, once on the night of the surgery and three times per day for five days following surgery. The effectiveness of the serrapeptase was assessed by measuring the changes in the patient’s facial swelling after the surgery. The results indicated that the patients treated with serrapeptase experienced less swelling in all the post-operative areas than those who received the placebo. More research is needed. In a more recent study, published in the Journal of Maxillofacial Oral Surgery, researchers investigated the effect of serrapeptase on facial swelling and pain caused by surgical removal of an impacted molar. After a systematic review of available clinical data on serrapeptase, the investigators concluded that the supplement could be used safely to alleviate pain and swelling in this type of oral surgery.
  • Anti-microbial: One of the main aims in the field of orthopedics is to find new ways to eliminate joint infection after implant surgery. A leading cause of this type of infection is the bacteria Staphylococcus aureus, which can kill cells that help fusion between the implant and the bone and cause infection and inflammation. In a 2017 study published in the International Journal of Immunopathology and Pharmacology human cells infected with staphylococcal strains were injected with serrapeptase. The results indicated that serrapeptase inhibited the staphylococcal infection. More studies are needed
  • Cardiovascular health: Blood clots inside your body can be extremely dangerous, particularly if you have one blocking an artery which supplies the heart or the brain. A clot is formed when plaque which ruptures in an artery stimulates clot formation. A fibrin mesh is formed trapping circulating red blood cells. If the clot obstructs the blood vessel completely, this can cause a heart attack or stroke. It is claimed that serrapeptase may support cardiovascular health by dissolving fibrin without causing harm to the surrounding healthy tissue. There is currently no clinical evidence to support this claim.

Many other health claims have been made about serrapeptase including its benefits for traumatic injury, ear infection, prostate problems, arthritis, osteoporosis, anti-aging, and angina. There is no clinical evidence to support any of these claims.

How to Take Serrapeptase

Because serrapeptase is not FDA approved, there is no standard recommended serrapeptase dosage. The suggested serrapeptase dosage, according to examine.com is 10-60 mg. When it comes to potency, this is measured in SPU (serratiopeptidase units) and SU (serrapeptase units), which are basically interchangeable.

Some products offer an SPU as low as 40,00 SPU, you should really be looking for a supplement that contains at least 80,000 SPU. Nutritionists recommend that you take serrapeptase on an empty stomach – 30 minutes prior to eating, or two hours after eating – three times per day.

Serrapeptase Side Effects and Precautions

Reported side effects include:

  • Skin rash
  • Diarrhea
  • Nausea
  • Vomiting

There is currently no information available about drug interactions with serrapeptase, or about toxic levels.

You should not take serrapeptase if you are pregnant, breastfeeding, or if you have any blood clotting disorders.

What to Look for in a Good Serrapeptase Supplement

Always look for a reputable manufacturer, who has been supplying serrapeptase for some time. Make sure the company has a clean track record and no complaints about them. A manufacturer whose products are made in a GMP-compliant facility is also preferable.

Choose a supplement that is free from common allergens, gluten, and artificial flavors, colors, or sweeteners. Whenever possible avoid supplements that contain unnecessary fillers. Your serrapeptase supplement should have an enteric coating to ensure that it’s not destroyed by acid in your stomach.

Top 10 Serrapeptase Products Compared

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1. Doctor’s Best High Potency Serrapeptase

Doctor's Best High Potency Serrapeptase

One of the best supplements on the market, Doctor’s Best High Potency Serrapeptase provides 120,000 SPU per serving. Serving size is one tablet. The bottle contains 90 capsules.

Specs

  • Provides 120,000 SPU per serving
  • Suitable for vegetarians
  • Enteric coating
  • Gluten-free
  • Non-GMO

Who Makes It?

Doctor’s Best was founded by a physician in 1990. Today, the company offers a range of more than 200 dietary supplements, most of which are made with proprietary formulas that are researched, manufactured, and tested to the most rigorous standards.

Bottom Line

As the name suggests, this is a high potency serrapeptase supplement, which makes it one of the top products of this kind. Not only is it gluten-free, non-GMO, and suitable for vegans, it is also has an enteric coating, which means it will be optimally absorbed.

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2. Best Naturals Serrapeptase

Best Naturals Serrapeptase

Best Naturals Serrapeptase provides 40,000 SPU per serving. Serving size is one tablet. The bottle contains 120 capsules.

Specs

  • Provides 40,000 SPU per serving
  • No artificial colors, flavors, or sweeteners
  • Suitable for vegetarians
  • Gluten-free
  • Contains no common allergens

Who Makes It?

Best Naturals refuses to compromise when health is at stake, and so they strive to produce the highest-quality dietary supplements following rigorous standards and offering them at competitive prices. The company sources the finest raw materials from the U.S. and overseas.

Bottom Line

Another good example of serrapeptase pills, particularly if you are looking for a less-potent supplement that you can take several times throughout the day. It contains no unnecessary ingredients or artificial additives. It is gluten-free and suitable for vegetarians.

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3. Source Naturals Serrapeptase

Source Naturals Serrapeptase

Source Naturals Serrapeptase provides 120,000 SPU per serving. Serving size is two tablets. The bottle contains 60 capsules.

Specs

  • Provides 120,000 SPU per serving
  • Suitable for vegetarians
  • Contains no common allergens
  • No added color, flavor, or sweeteners
  • Gluten-free

Who Makes It?

 Ira Goldberg created Source Naturals in 1982, after noticing that the kind of nutritional supplements he was looking for didn’t yet exist – those with combined ingredients that optimized health benefits. Since then the company has been a forerunner in the dietary supplement market. Today Source Naturals till focuses on educating and empowering individuals about their health.

Bottom Line

This is a strong serrapeptase supplement with a highly reputable manufacturer behind it. It has a high potency and it is free from gluten and common allergens. It contains no artificial or unnecessary additives, and its vegetarian-friendly.

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4. Sunergetic Best Serrapeptase Enzyme Supplement

Sunergetic Best Serrapeptase Enzyme Supplement

Sunergetic Best Serrapeptase Enzyme Supplement provides 40,000 SU per serving. Serving size is one tablet. The bottle contains 90 capsules.

Specs

  • Provides 40,000 SU per serving
  • Kosher certified
  • Suitable for vegetarians
  • Enteric coating
  • Contains fillers

Who Makes It?

Sunergetic is a U.S.-based company that makes premium supplements from high-quality ingredients. All the ingredients are natural and non-GMO. Their aim is to provide nutritional support for a healthy lifestyle. All their products are manufactured in the USA in an FDA registered facility.

Bottom Line

Sunergetic has produced a powerful serrapeptase supplement that is made with high-quality ingredients. THe mild dosage allows you freedom to take several capsules throughout the day. The veggie capsules are Kosher certified.

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5. Solaray Serrapeptase

Solaray Serrapeptase

Solaray Serrapeptase provides 20,000 SU per serving. Each serving is one tablet. The bottle contains 90 tablets.

Specs

  • Provides 20,000 SU per serving
  • Suitable for vegetarians
  • Enteric coating
  • Contains fillers
  • Good reviews

Who Makes It?

Solaray is the flagship brand of the company Nutraceutical. It was founded in Utah in 1973. The company manufactures more than 1,000 products including vitamins, minerals, herbal supplements, and speciality supplements such as probiotics, digestive enzymes, and amino acids.

Bottom Line

This is not a very effective serrapeptase supplement as it only provides 20,000 SU per serving. To get a potent dose you would need to take 3-4 tablets. It also contains fillers.

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6. Enerex Serrapeptase

Enerex Serrapeptase

Enerex Serrapeptase provides 120,000 SU per serving. Serving size is one capsule. The bottle contains 120 tablets.

Specs

  • Provides 120,000 SU per serving
  • Delayed release capsules
  • Suitable for vegetarians
  • Contains fillers

Who Makes It?

Enerex Botanicals is a Canadian company based in British Columbia. The company was developed in 1997. Enerex has a range of proprietary nutraceuticals. Their team is dedicated to providing supplements that contain pure ingredients that meet the highest safety standards.

7. Nova Nutritions Serrapeptase

Nova Nutritions Serrapeptase

Nova Nutritions Serrapeptase provides 40,000 SU per serving. Serving size is one tablet. The bottle contains 180 capsules.

Specs

  • Provides 40,000 SU per serving
  • Gluten-free
  • Suitable for vegetarians
  • Contains no common allergens
  • No preservatives

Who Makes It?

Nova Nutritions has a GMP certified facility based in in New Jersey. They are committed to only using ingredients that meet their stringent quality standards. They provide a range of high-quality supplements at affordable prices.

Bottom Line

This supplement has a relatively low serrapeptase potency. However, the quality is good. It contains no artificial flavors, colors or sweeteners. It is gluten-free, vegetarian and free from common allergens. It is also good value for money.

8. Natures Aid Serrapeptase

Natures Aid Serrapeptase

Natures Aid Serrapeptase provides 80,000 SU per serving. Serving size is one tablet. The bottle contains 90 capsules.

Specs

  • Provides 80,000 SU per serving
  • Suitable for vegetarians
  • Gluten-free
  • Contains fillers
  • No preservatives

Who Makes It?

Natures Aid is a U.K.-based company that was established in 1981. They are one of the U.K.’s most popular brand of supplements. They have a wide range of vitamins, minerals, and herbal supplements.

Bottom Line

This is an affordable serrapeptase supplement with a strong potency. One the good side, it’s gluten-free and contains no preservatives. On the down side, it does contain a lot of fillers.

9. Smart Nutrition Serrapeptase

Smart Nutrition Serrapeptase

Smart Nutrition Serrapeptase provides 50,000 SU per serving. Serving size is one tablet. The bottle contains 120 capsules.

Specs

  • Provides 50,000 SU per serving
  • Suitable for vegetarians
  • Contains fillers
  • Affordable price
  • Good reviews

Who Makes It?

SMART Nutrition supplies a small range of nutritional supplements and eye drops. No information is available about the company.

Bottom Line

This is an average supplement with quite a low potency. It is vegetarian but does contain fillers.

10. Pure Naturals Serrapeptase

Pure Naturals Serrapeptase

Pure Naturals Serrapeptase provides 40,000 SU per serving. Serving size is one tablet. The bottle contains 90 capsules.

Specs

  • Provides 40,000 SU per serving
  • No preservatives
  • No artificial sweetener or flavors
  • Contains no common allergens
  • Contains fillers

Who Makes It?

Pure Naturals is a U.S.-based company that was established in 2014. Every product is thoroughly tested throughout the manufacturing process. None of their products contain artificial colors, flavors, sweeteners.

Bottom Line

This serrapeptase supplement has good value and it is made without artificial additives. However, it does contain fillers.

Austin Meadows

Written by Austin Meadows

Austin Meadows is an independent writer and consultant specializing in health and wellness topics. With more than 7 years of experience writing in the natural health industry, Austin strives to deliver accurate, concise and researched based information to his readers. You can find more of Austin's work at Olympic-Creative.com, or connect with him on LinkedIn.